We use cookies to give you the best experience possible. By continuing we’ll assume you’re on board with our cookie policy

See Pricing

What's Your Topic?

Hire a Professional Writer Now

The input space is limited by 250 symbols

What's Your Deadline?

Choose 3 Hours or More.
Back
2/4 steps

How Many Pages?

Back
3/4 steps

Sign Up and See Pricing

"You must agree to out terms of services and privacy policy"
Back
Get Offer

Chm 556

Hire a Professional Writer Now

The input space is limited by 250 symbols

Deadline:2 days left
"You must agree to out terms of services and privacy policy"
Write my paper

UNIVERSITI TEKNOLOGI MARA COURSE INFORMATION Confidential Code Course Level Credit Hours Contact Hours : : : : : CHM 556 Organic Chemistry II Degree 4 3 hr (Lecture) 3 hr (Practical) 3 Core CHM 456 Part Course Status Pre-requisite : : : Course Outcomes : Upon completion of this course, students should be able to: 1. Determine functional groups present in organic compounds using Infrared Spectroscopy and interpret Nuclear Magnetic Resonance spectra and relate the information to structural features of organic compounds.

State and explain principles governing the physical and chemical properties of aldehydes, ketones, carboxylic acid, carboxylic acid derivatives and amines.

Don't use plagiarized sources. Get Your Custom Essay on
Chm 556
Just from $13,9/Page
Get custom paper

Write, explain and solve problems related the reaction mechanisms for nucleophilic addtition of carbonyl compounds and nucleophilic acyl substitution of carboxylic acids and their derivatives. Develop synthetic methods for preparations of various types of aldehydes, ketones, carboxylic acids, carboxylic acid derivatives and amines. Plan, conduct, observe and report experiments in organic chemistry . 3. 4. 5. Course Description : This course is a continuation of the study of organic chemistry begun in Organic Chemistry I. This course begins with an introduction to the use of infrared and nuclear magnetic resonance (NMR) spectroscopy in the determination of the structures of organic molecules.

The chemistry and physical properties of carbonyl containing compounds such as aldehydes, ketones, carboxylic acids and carboxylic acid derivatives forms the major part of the course. Reactions involving enolate anions as nucleophiles are discussed.

The emphasis of this course is on the development of problem solving skills in the context of structure features, synthesis and mechanism of reactions of carbonyl compounds. The chemistry of amines and overview of carbohydrate are also included. Syllabus Contents 1. 0 Spectroscopy of Carbon Compounds 1. 1 1. 2 1. 3 2. 0 Introduction to Spectrocopy and Structural Identification Infrared Spectroscopy Proton and Carbon-13 Nuclear Magnetic Resonance Spectroscopy Aldehydes and Ketones I: Oxidation, Reduction and Synthesis 2. 2. 2 Introduction: Nomenclature; Physical properties Reduction 2. 2. 1 Catalytic Reduction 2. 2. 2 Hydride Reducing Reagents: NaBH4, LiAlH4 2. 2. 3 Complete Removal of Carbonyl group; Clemmensen and Wolf-Kishner Reduction Synthesis of Aldehydes and Ketones Through Reduction of Acid Chlorides and Esters 2. 3. 1 Rosenmund Reduction 2. 3. 2 DIBAL-H Synthesis of Aldehydes through Oxidation of Alcohols o o 2. 4. 1 Oxidation of 1 and 2 Alcohols 2. 4. 2 Jones, Sarret and PCC Reagents 2. 4. 3 Tollen’s Test 2. 3 2. 4 3. 0

Aldehyde and Ketone II: Nucleophilic Additions to the Carbonyl Group 3. 1 3. 2 3. 3 3. 4 3. 5 Reactivity of Carbonyl Group; Nucleophilic Addition Cyanohydrin Formation; Synthesis of ? -hydroxy acids and hydrolysis of nitriles Addition of Organometallic Reagents; Grignard and alky lithium reagents Addition of Water; Hydrates Addition of Alcohols; Acetals and Hemiacetals 3. 5. 1 Cyclic Acetals 3. 5. 2 Protecting Group using Acetals Addition of Amines 3. 6. 1 Imines from 1o Amines 3. 6. 2 Enamines from 2o Amines 3. 6. 3 Enamines for Alkylation of Ketones Wittig Reaction . 6 3. 7 4. 0 Carbohydrates 4. 1 4. 2 4. 3 4. 4 4. 5 4. 6 Carbohydrate Structures; Fischer Projections; D and L Notations Cyclization of Monosaccharides; Furanose and pyranose rings Haworth Projections and Chair Forms; Anomers Converting Fischer Projections to Haworth Projections Mutarotation Reactions of Carbohydrates 4. 6. 1 Reduction and Oxidation 4. 6. 2 Conversion to Acetal; Formation of glycosides Disaccharides and Polysaccharides

4. 7 5. 0 Carboxylic Acids 5. 1 5. 2 Nomenclature; Physical Properties Synthesis of Carboxylic Acids 5. . 1 Oxidation of 1o Alcohols 5. 2. 2 5. 2. 3 5. 2. 4 5. 3 Side chain Oxidation of Aromatic Compounds Carbonation of Grignard and Alkyl Lithium Compounds Hydrolysis of Nitriles 5. 4 6. 0 Acidity of Carboxylic Acids 5. 3. 1 Formation of Carboxylate Ion 5. 3. 2 Protonation and Deprotonation 5. 3. 3 Effects of Electron-withdrawing and Electron-donating Groups on Acidity Decarboxylation of Carboxylic Acids Derivatives of Carboxylic Acid 6. 1 Nomenclature of Acid Derivatives 6. 1. 1 Acid Chlorides 6. 1. 2 Acid Anhydrides 6. 1. 3 Esters 6. . 4 Amides Acyl Functional Group Interconversion; Nucleophilic Acyl Substittution 6. 2. 1 Reactivity of Carbonyl of the Acyl Groups 6. 2. 2 Reactions of Acid Chlorides and Acid Anhydrides (no catalyst); Hydrolysis, Alcoholysis, Aminolysis. 6. 2. 3 Reactions of Esters and Amides (with catalyst); Fischer Esterification, Transesterification and Hydrolysis. Acylation of Enamines Miscellaneous Reactions of Acid Derivatives 6. 4. 1 Esters with Organometallic Reagents 6. 4. 2 Reduction of Esters and Acid Chlorides 6. 2 6. 3 6. 4 7. 0

Reactions of ? -Hydrogen 7. 1 7. 2 Acidity of ? -Hydrogens: Enolate Anions; Keto and Enol Tautomers Alkylation and Halogenation Reactions 7. 2. 1 Akylation of Ketones 7. 2. 2 Halogenation; ? -Bromination and haloform reactions 7. 3 7. 4 Aldol Condensation 7. 3. 1 Mechanism; Addition of Enolate Anions to Carbonyls; Dehydration of Product 7. 3. 2 Crossed Aldol Condensation and Synthetic Applications 7. 3. 3 Cyclization via Aldol Condensation; Formation of Rings Claisen Condensation 7. 4. 1 Mechanism of Claisen Ester Condensation 7. 4. Dieckmann Condensation Conjugate Addition of ? ,? -unsaturated Carbonyl Compounds; Michael Addition Robinson Annulation Acetoacetic Ester and Malonic Ester Synthesis; Formation of Enolates, Alkylation, Hydrolysis and Decarboxylation 7. 5 7. 6 7. 7 8. 0 Amines 8. 1 8. 2 8. 3 8. 4 Nomenclature; Structure; Classification; Physical Properties; Basicity of Amines Biologically Important Amines Synthesis of Amines 8. 4. 1 Gabriel Synthesis 8. 4. 2 Reductive Amination 8. 4. 3 Hoffmann Rearrangement Reactions of Amines 8. 5. 1 Reaction with Nitrous Acid 8. . 2 Replacement Reaction of Arenediazonium Salts 8. 5. 3 Coupling Reaction of Arenediazonium Salts 8. 5 Practicals 1. Aldehyde and ketone : characterization of an unkown 2. Sodium borohydride reduction of 4-tert-butylcyclohexanone 3. Methyl benzoate by Fischer esterification 4. Aldol Condensation reaction: Preparation of dibenzalacetone 5. Preparation of 4,4-Dimethyl-2-cyclohexen-1-one 6. Isolation of natural product; Caffeine form Tea 7. Synthesis of acetanilide from aniline Teaching Methodology Lectures and laboratory sessions.

Assessment Assignments Test Laboratory report Final examination Recommended Text Solomons and Fryhle. 9 Edition. Organic Chemistry. Wiley 2007 References McMurry, J. Organic Chemistry, Brooks and Cole 2007 Smith, J. G. Organic Chemistry 2ed. McGraw Hill 2007 Wade, L. G. 7th Edition. Organic Chemistry, 2010. Seyhan Ege, 5 Edition, Organic Chemistry: Structure and Reactivity, Houghton Mifflin, 2004. Pavia, Lampman, Kriz and Engel, 2 Edition, Introduction to Organic Laboratory Techniques: A Small Scale Approach, Thomsom Brooks/Cole, 2004. nd th th : : ; : 10% 30% 20% 40%

Cite this Chm 556

Chm 556. (2016, Oct 01). Retrieved from https://graduateway.com/chm-556/

Show less
  • Use multiple resourses when assembling your essay
  • Get help form professional writers when not sure you can do it yourself
  • Use Plagiarism Checker to double check your essay
  • Do not copy and paste free to download essays
Get plagiarism free essay

Search for essay samples now

Haven't found the Essay You Want?

Get my paper now

For Only $13.90/page