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Essay – Nitric Oxide

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    The supplement that I chose was Nitric Oxide. This is a very up and coming supplement in the industry and although not many studies have been done on the long term effects many more gym goers are jumping on the band wagon and experiencing the benefits of it. Some history on Nitric Oxide is that it was first discovered in 1772 by Joseph Priestly, who called it “nitrous air,” nitric oxide was first discovered as a colorless, toxic gas. Unfortunately, the classification of toxid gas and air pollutant continued to be the only labels nitric oxide was afforded until 1987, when it was shown to actually be produced naturally in the body. as named Molecule of the Year by Science in 1992, this is an annual award made by the journal Science for the most significant development in scientific research. The 1998 Nobel Prize in Medicine or Physiology was awarded to Robert F. Furchgott, Ferid Murad, and Louis J. Ignarro for their discoveries of the role of nitric oxide in cardiovascular physiology So what Is Nitric Oxide? Chemically Nitric Oxide is Nitric Oxide is composed of 1 Oxygen Atom and 1 Nitrogen Atom. Nitric Oxide is a free form gas that is produced in the body and is used by the body to communicate with other cells in the body.

    To produce this gas, enzymes in the body break down the amino acid Arginine. The production of Nitric Oxide occurs when the amino acid L-arginine is converted into L-citruline through an enzyme group known as Nitric Oxide Synthase. Nitric Oxide helps to controls the circulation of blood, and transmits messages between nerve cells. So how Nitric Oxide works is Nitric Oxide is produced within the flat endothelial cells that line the inside of blood vessels. When the endothelial cell is stimulated–such as when the muscle contracts–it synthesizes and releases Nitric Oxide.

    Once released, Nitric Oxide diffuses across the endothelial cell membrane into the adjacent smooth muscle tissue of the blood vessels, causing them to relax and widen (a process called vasodilation). The result is an increase in blood flow to the stimulated area. A major benefit from this when working out is that nutrients are being brought into the muscle at a faster rate, at the same time, the byproducts of metabolism are also transported out of the muscle (carbon dioxide and lactic acid) which fatigue the muscle and inhibit performance.

    Everyone needs NO to carry out key functions of the body such as sending blood to a certain area of the body, forming blood clots, helping with the immune system and more. Some uses of NO include : blood pressure can be lowered while both blood flow and blood vessel diameter are improved. Nitric Oxide also helps in the formation of blood clots. You find endothelial cells that help in the controlling and relaxing of blood vessels, and this is helped with the use of Nitric Oxide.

    With widened blood vessels, this can offer protection to the heart from damage and increase the supply of oxygen to the body. It is also possible to establish regular electrical impulses and Nitric Oxidermal rhythm to the heart through Nitric Oxide Weight loss :Inside the cells of the body are tiny mitochondria, the places where food and oxygen are turned into energy. The mitochondria is where all fat is burned, in addition to generating almost all of a persons energy used and controlling cellular metabolism.

    Research is showing that nitric oxide not only stimulates the creation of new mitochondria, but also may make each individual mitochondrion larger, which helps burn even more fat and therefore could result in weight loss. Erectile dysfunction: Several researches on the efficacy of nitric oxide on penile erection, have reported positive effects of both chemicals in stimulating and maintaining erection. In fact, one of the effects of Viagra is increasing the amount of Nitric Oxide in the body as Nitric Oxide lengthens and heightens the time of stimulation.

    Nitric oxide also aids the body in the healing process after suffering from abrasions, cuts, wounds, muscle and ligament injury, etc. Proper supply of nitric oxide also protects people from atherosclerosis where the arteries or the blood vessels become hardened. The immune system is also benefited from Nitric Oxide as the immune cells generally release Nitric Oxide to kill bacteria, and both parasitic and viral infections. The production of the blood cells in the bone marrow is enhanced with Nitric Oxide supplements, wherein the number of immune boosting “Killer T-Cells” is increased.

    Nitric Oxide is also a great mediator for both rheumatism and inflammation as it helps to relieve pain. Scientific research shows that the pain-relieving effects of medications like morphine, aspirin, and oxycontin are due to the release of nitric oxide. , A No deficiency can lead to the following problems : High blood pressure, Thrombosis, Inflammation, Obesity, Blood fat disorders, Diabetes (both type I and II, Heart failure, Atherosclerosis (hardening of the arteries),Pre-mature aging…All of which don’t sound very appealing to me. Some foods that Nitric Oxide can be found n an everyday diet include: L-arginine can be found in chocolate, wheat germ and flour, buckwheat, granola, oatmeal, dairy products (cottage cheese, ricotta, nonfat dry milk, skim yogurt), beef, pork, nuts, and poultry. Most individuals will naturally consume between 1-2 grams of L-Arginine in a given day (closer to the 2 gram mark if you eat a lot of red meat). This needs to be taken into consideration as the total amount of L-Arginine consumption is best limited to 9 grams a day, Some effects of taking to much Nitric Oxide are Nausea, Mild headaches, Change in blood pressure, Diarrhea.

    Most of these side effects are actually pretty common when Nitric Oxide is taken in excess so one has to be careful in how much they ingest. A recent study at Baylor University’s (Texas) Exercise and Sports Nutrition Lab examined the effects of NITRIC OXIDE supplementation during training on body composition and training adaptations in experienced gym rats (16). Thirty-five resistance-trained males were matched according to fat-free mass and randomly assigned to ingest supplements containing either a placebo or commercial NITRIC OXIDE supplement in a double blind manner.

    Subjects took four grams of the supplements three times daily (12 grams per day) for eight weeks during standardized training. There were no significant changes in body mass or body composition. However, there were significant changes in strength levels. The bench press one repetition maximum (1RM) was greatly increased over the eight week period for the NITRIC OXIDE group. Specifically NITRIC OXIDE supplementation helped subjects add an average of 13 pounds to their bench press max over the placebo group during the eight week testing period.

    It may be interesting to note that although body composition did not change during the study a longer duration experiment may have shown an increase in lean muscle mass for the NITRIC OXIDE group. In fact muscle mass is often accompanied by changes in strength as seen in most studies but may take as long as 12-16 weeks to fully maximize physiological responses and processes in terms of muscular hypertrophy Experts are of the opinion that there are very less chances of nitric oxide side effects, if one takes the correct dosage.

    You have to read the instructions given on the label very carefully before taking these supplements. Initially, start with a very less dose, gradually increasing your intake as you see less side effects and more benefits. If you experience any of the severe side effects, do not waste time to consult your physician. Even before taking these nitric oxide boosters or supplements, discuss with your health practitioner. Women who are pregnant or nursing their babies, and those who have heart and liver problems, should refrain from taking nitric oxide supplements, as it is toxic for their body.

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