We use cookies to give you the best experience possible. By continuing we’ll assume you’re on board with our cookie policy

See Pricing

What's Your Topic?

Hire a Professional Writer Now

The input space is limited by 250 symbols

What's Your Deadline?

Choose 3 Hours or More.
Back
2/4 steps

How Many Pages?

Back
3/4 steps

Sign Up and See Pricing

"You must agree to out terms of services and privacy policy"
Back
Get Offer

Making a Paracetamol

Hire a Professional Writer Now

The input space is limited by 250 symbols

Deadline:2 days left
"You must agree to out terms of services and privacy policy"
Write my paper

Making paracetamol This is one of the practicals that is available at The Salters Chemistry Club for students. It has been reworked for general use here on TecHKnow Wiki Technician requirment for practical * 4-aminophenol * Clean appropriate size glassware * Access to Magnetic stirrer(s) * Buchner funnel and conical flash (filtering under vaccum) * Ice * Hotplate/bunsen burner * Oven (set at 45OC) Risk Assessment -aminophenol and ethanoic anhydride, are both IRRITANT’s- avoid contact with hands or breathing in vapours. If contact with skin or eyes wash with water: Paracetamol is dangerous in large quantities.

Wear safety glasses, gloves and lab coat How it’s made Paracetamol is one of the most common drugs used in the world, and is manufactured in huge quantities. The starting material for the commercial manufacture of paracetamol is phenol, which is nitrated to give a mixture of the ortho and para-nitrotoluene.

Don't use plagiarized sources. Get Your Custom Essay on
Making a Paracetamol
Just from $13,9/Page
Get custom paper

The o-isomer is removed by steam distillation, and the p-nitro group reduced to a p-amino group. This is then acetylated to give paracetamol.

Method * Place 2g of the 4-aminophenol into a 50cm3 conical flask, add 15cm3 of water and stir the suspension vigorously (magnetic stirrer) for a few minutes. * Add 2. 2cm3 of ethanoic anhydride and continue stirring until the suspension dissolves and a precipitate (Paracetamol) eventually forms. * After 10 minutes filter the precipitate (using a buchner funnel), washing with small amounts of cold, distilled water. After drying, the crude product should be placed in a clean 100cm3 conical flask and recrystalised by heating until it just dissolves in approximately 20cm3 of water. * Cool the flask in ice until crystals of the purified paracetamol appear. * Filter the crystals under vacuum, dry in a warm oven and then record the melting point and compare with standard paracetamol tablets (~170oC). * Repeat recrystalisation process to achieve a more purer product

Cite this Making a Paracetamol

Making a Paracetamol. (2017, Jan 31). Retrieved from https://graduateway.com/making-a-paracetamol/

Show less
  • Use multiple resourses when assembling your essay
  • Get help form professional writers when not sure you can do it yourself
  • Use Plagiarism Checker to double check your essay
  • Do not copy and paste free to download essays
Get plagiarism free essay

Search for essay samples now

Haven't found the Essay You Want?

Get my paper now

For Only $13.90/page