The Effect of the Different Forms of Acetaminophen on Solubility
Some consumers want to know if acetaminophen dissolves faster in the form of tablets, gelcaps, or caplets in order to get the fastest pain relief - The Effect of the Different Forms of Acetaminophen on Solubility introduction. The purpose of this experiment was to find out which of the three tested forms of acetaminophen would dissolve the most over a time period ten minutes. The hypothesis stated that the tablets would dissolve the most over the ten minutes. The hypothesis was tested by dropping ten of each of the forms of the acetaminophen into two thirds a cup of boiling water and observing how much each had dissolved after ten minutes.
The data collected supported the hypothesis and the tablets were significantly more dissolved than the gelcaps and caplets. This experiment could be changed by having a component stir the acetaminophen and the water together. Introduction The solubility of medicine is important because the quicker it dissolves, the quicker is can start working. There are many different forms of Acetaminophen on the market. This experiment is an attempt to discover which form of Acetaminophen will dissolve the quickest and most complete.
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Acetaminophen was accepted for use by the Food and Drug Administration in 1951 (Ogbru 1). It is an analgesic, or a drug that helps relieve a person of aches and pains (Ogbru 1). Acetaminophen is also an antipyretic, which are drugs that lower a person’s elevated body temperature (Ogbru 1). These kinds of drugs are used by many people everyday. Acetaminophen is a compound including: Carbon, Hydrogen, Nitrogen, and Oxygen (Acetaminophen 1). The molecular formula is C8H9NO2 (Acetaminophen 1). N-(4-Hydroxyphenyl) acetamide is the chemical name of Acetaminophen (Acetaminophen 1).
Paracetamol, Tempra, and Tylenol are some of the other different brand names used for it (Acetaminophen 1). Acetaminophen is described as a white, odorless powder (Acetaminophen 1). Solubility is the capability of one substance to be dissolved by another (Butt 587). Acetaminophen is a soluble compound; it dissolves well in alcohol or boiling water (Acetaminophen 1). The three forms of Acetaminophen used in this experiment are: caplets, chewable tablets, and rapid release gel caps. Soluble means that something is able to be dissolved (Butt 587).
In most cases, as the temperature of the solvent increases, the rate at which the solute dissolves increases as well (Martin 1). In order to break the bonds holding the molecules in a solute together, heat is often needed (Ophardt 1). A solvent is a substance that dissolves another substance (Butt 587). The solute is known as the substance that is being dissolved (Butt 587). Diffusion is the mixing of the atoms or molecules of one substance with those of another according to The World Book: 2000 Edition (Butt 201). Diffusion is set off by the normal movements of atoms or molecules (Butt 201).
This happens consistently in gases and liquids because of the perpetual and random motion of their atoms and molecules (Butt 201). The World Book: 2000 Edition defines osmosis as the movement of a liquid from one solution through a special membrane into a more concentrated solution (Butt 865-866). While osmosis is occurring, some of the solvent from one solution travels through microscopic holes in a membrane into another solution (Butt 865-866). The membrane is semi-permeable, which means it lets solvent molecules go through its holes, but it stops solute molecules that are bigger than the holes in the membrane (Butt 865-866).
This experiment was conducted to find out which of the three tested forms of acetaminophen would dissolve the most in hot water over a period of ten minutes. The hypothesis stated that the tablets would dissolve more than the gelcaps or caplets over the time allotted. Materials and Methods The materials needed to conduct this experiment are: a tea pot (or regular pot), ten identical glass containers, measuring cup, stove, ten tablets, ten gelcaps, ten caplets, clock to keep time with, and water.
Once all the materials needed are readily available put a tea pot (or regular pot) filled with water on the stove and bring to a boil. Set out the ten glass containers. When the water is boiling pour two-thirds a cup of the hot water into each container, and drop the first form of Acetaminophen in. Make sure only one pill goes in each container. Wait ten minutes and then observe how much each pill has dissolved. Record results and repeat steps for each different form. Results The effect of the different forms of acetaminophen on solubility is summarized in table 1 and table 2.
The tablets dissolved from a fifty to seventy-five percent range on average after ten minutes. However the gelcaps and caplets only dissolved twenty-five percent after ten minutes in the majority of the trials. The tablets and caplets had slight variations throughout the ten trials, but the gelcaps had a consistent result each time. Based on this data the tablet’s outcome was significantly different from both the gelcaps and caplets. The data supported the hypothesis that the tablets would dissolve the most over a time period of ten minutes.
Conclusion The purpose of this experiment was to investigate the effect of the different forms of acetaminophen on solubility. The major finding in this experiment was that the tablet’s outcome was significantly different from both the gelcaps and caplets. The data supported the hypothesis that the tablets would dissolve the most over a time period of ten minutes. The manufacturers of the gelcaps and caplets both stated that their product is fast releasing. However the tablet’s manufacturer did not suggest that their product is fast releasing.
Ironically, based on the results of this experiment, the tablets were the only form that dissolved over twenty-five percent the majority of the ten trials. The tablets may have dissolved the most because they were the only chewable form. This experiment could be improved by comparing a wider variety of forms of acetaminophen, changing the time allotted for the different forms to dissolve, using different levels of pH, or having a component stir the acetaminophen and the water together. It could be altered slightly by timing the different forms of acetaminophen to measure how fast they dissolve.