Leonardo da Vinci was born in 1452 in the Republic of Florence. He was a painter, sculptor, architect and engineer who is best known for his paintings, including Mona Lisa and The Last Supper. In 1469, he began his apprenticeship with artist Andrea del Verrocchio; his first major commission came in 1481 when he was asked to paint an altarpiece for the church of San Francesco in Milan. In 1482, Leonardo da Vinci moved to Milan to work for Duke Ludovico Sforza; there he remained for 17 years during which time he painted portraits of both the duke and his family as well as The Last Supper. Leonardo da Vinci is best known for his paintings, such as the Mona Lisa and The Last Supper, as well as for his drawings and sculptures. In 1500, da Vinci returned to Florence from Milan, where he had been working on engineering projects for Ludovico Sforza. He also worked on painting and sculpting projects in Florence, including a monumental horse-drawn chariot. In 1513 da Vinci traveled to Rome at the invitation of Pope Leo X; there he worked on projects for the Vatican until his death in 1519.