Annotated Bibliography - Part 2

Annotated Bibliography

     Vitoux, D., Nasr, R., and de The, H - Annotated Bibliography introduction. (2007). Acute promyelocytic leukemia: New issues on pathogenesis and treatment response. The International Journal of Biochemistry & Cell Biology, 39, 1063–1070.

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     The article “Acute promyelocytic leukemia: New issues on pathogenesis and treatment response” published in the International Journal of Biochemistry & Cell Biology in 2009, 39th issue was written by Dominique Vitoux, Rihab Nasr and Hugues de The. The authors are from Saint-Lois Hospital of Paris and have published several articles pertaining to this subject. The main reason from writing this article is to enhance the understanding of the readers about the pathogenesis of promyelocytic leukemia. In fact, of all the human malignancies, the most well understood malignancy is acute promyelocytic leukemia and the authors intend to dissipate this knowledge to other health professionals. Infact, it is because of such good understanding that this disease is one of the first of its kind to be treated with oncogene targeted therapies.

The article begins with an abstract which highlights the main discussion aspects in the article. The introduction of the article is elaborate and includes cardinal features of the disease, genetic aspects of the malignancy and various therapies developed to treat the disease. The introduction is followed by the main discussion portion of the article, the pathogenesis of acute promyelocytic leukemia.

The pathogenesis is described in an elaborate manner under 3 good and comprehensive-friendly headings. Good studies have been used for referencing. The genetic component of the pathogenesis is mainly stressed upon. Pathogenesis is then followed by therapy, which again is discussed under 4 headings. This section deals with various therapeutic options that have come forth for the treatment of promyelocytic leukemis, based on the discussions about the pathogenesis of the disease. The article ends with a small conclusion which provides a gist of what has been discussed on the article. This article is mainly aimed to enhance the understanding of oncologists, cancer research scientists, medical students and other health professionals dealing with clinical aspects and research of promyelocytic leukemia. The language is easy to understand and the flow of ideas is smooth. This is a good article that can be recommended for those interested in knowing the pathogenesis of promyelocytic leukemia. There is a long reference list at the end of the article, presented in Harvard style. Most of them are primary articles which uphold the reliability and accuracy of information provided in this article.

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