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Charcot Marie Tooth Disease Essay, Research Paper

Charcot-Marie-Tooth Disorder

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Charcot-Marie-Tooth Disorder ( CMT ) is the most common type of familial motor and centripetal neuropathy ( HMSN ) , happening in one of every 2500 births. The average age of oncoming of clinical symptoms is 12.2 ± 7.3 old ages. Badness of the upset varies among the single and among the subtypes of CMT. Subtypes are distinguishable by proving the nervus conductivity speed ( NCV ) , musculus biopsies, and protein degrees in cerebrospinal fluid. Three different subtypes have been identified, appropriately called CMT I, CMT II, and CMT III ( or Dejerine-Sottas disease ) .

( Epstein 1993 )

CMT I shows a to the full penetrant phenotype. The oncoming of clinical symptoms is normally seen by the age of two. Common characteristics of this upset include foots cavus, a malformation of the pes characterized by an abnormally high arch and hyperextension of the toes, which gives the pes a claw-like visual aspect, and cock toes. As CMT progresses, failing and wasting of leg musculuss occur. Areflexia occurs in the Achilles and patellar countries ( absence of physiological reaction ) , and subsequently musculus debasement affects the intrinsic musculuss in the custodies.

CMT II has a similar clinical phenotype to CMT I, but with a wider scope of the age of oncoming and ulterior visual aspect of symptoms. There is besides less engagement of manus musculuss. Dejerine-Sottas Syndrome ( DSS or CMT III ) is the rarest signifier of CMT. This syndrome portions clinical, electrophysiological, and pathological findings of CMT I. However, the oncoming of DSS is by and large during babyhood and the symptoms are typically more terrible.

The causes of CMT have been linked to autosomal dominant, autosomal recessive, X-linked, and environmental agencies. The largest figure surveies have been done on CMT-IA ( an autosomal dominant signifier ) , the most common signifier of CMT. It is frequently associated with a 1.5 megabase tandem duplicate of the short arm of chromosome 17 ( 17p12 ) found in about 70 per centum of unrelated CMT I patients. It is thought that this duplicate is a consequence of unequal crossing-over between two chromosome 17 s during miosis. ( King 1998 ) Studies of CMT-IA have indicated that it is a demyelinating neuropathy. The tandem duplicate of chromosome 17 includes the PMP22 cistron. This cistron is responsible for encoding a protein expressed in the compact medulla of a peripheral nervus. The exact physical size of the duplicate is unknown, but the Deoxyribonucleic acid markers found within the duplicate spans a distance of 14 centimorgans on the female meiotic map and four centimorgans on the male meiotic map. ( Lupski et al. 1992 )

It has been suggested that increased cistron dose of PMP22 is the mechanism by which DNA duplicate gives rise to the CMT-IA phenotype. A survey was done to prove the undermentioned hypothesis: if the part duplicated in CMT-IA patients was contained wholly within the big duplicate in the partial 17p trisomy patients, and the patients met electrophysiological diagnosings of CMT-IA, the cistron dose theoretical account would be supported. Cytogenetic and molecular analyses indicate that a cistron dose consequence is so responsible for the electrophysiological phenotype associated with CMT-IA. The theoretical account of break of a campaigner CMT-IA cistron at the duplicate junction can be refuted because the Deoxyribonucleic acid markers are both proximal and distal to the duplicate. Linkage analysis of CMT households is non consistent with two chromosome 17p venue so this regulations out the possibility of two cistrons doing the phenotypes. ( Lupski et al. 1992 ) This survey indicates that a cistron dose consequence may be responsible for other Mendelian disease phenotypes. This may let scientists to develop curative intercessions aiming the cistron merchandises.

PMP22 is non the lone cistron that has been linked to CMT. Mutants in the mpz ( myelin protein nothing ) cistron have been linked to over 40 mutants that have resulted in either CMT-IB or DSS. The cistron Cx32 explains the assorted CMTI/CMTII and CMTX fluctuations of CMT. Cx32 mutants are the 2nd most prevailing mutant found in CMT-I. Over 150 mutants have been described, including omissions, missense, bunk, and frameshift mutants. Unlike PMP22 and mpz, the scope of clinical badness is much less in males. ( Warner et al. 1999 ) This makes genotype and phenotype correlativity really hard. With a assortment of cistrons thought to be responsible for CMT, clinicians must trust on complex molecular methods to find which cistron is playing a function.

The DNA duplicate associated with CMT-IA requires FISH ( fluorescence in situ hybridisation ) analysis of interphase karyon. Molecular analysis utilizing DNA markers is besides used to map within the duplicated part. ( Roa et al. 1996 ) Cytogenetic analysis of metaphase chromosomes is non plenty to observe this mutant, chiefly because the p arm of chromosome 17 is really short. It is for this ground that most instances of CMT are non detected until after the kid is born.

A instance survey of four patients with de novo partial duplicates of 17p was investigated for neuropathological marks of CMT-IA. Two showed revealing marks of the upset ( a decreased nervus conductivity speed ) , while the other two had normal NCVs. Cytogenetic and FISH analysis was performed, along with molecular surveies to find whether a duplicate of the PMP22 cistron was present. One patient ( # 621 ) had a reduced NCV and showed an upside-down duplicate of 17p13.3 ® p11.2. In add-on to patient 621, three others were studied. These persons besides had the 17p partial trisomy, a direct duplicate of sets 17p11.2 ® p12. However, merely one of these three showed a reduced NCV.

Southern analyses were performed utilizing Deoxyribonucleic acid markers to place and map the duplicated part. These surveies found the PMP22 cistron duplicated in those patients with a reduced nervus conductivity speed. However, patients that had the 17p trisomy with a normal NCV did non demo duplicate for the cistron. Using RFLP analysis, it was determined that this cistron was maternal in beginning. ( Roa et al. 1996 )

Fish analysis showed patients with the duplicated PMP 22 cistron exposing four ruddy signals. In contrast, patients that did non hold the duplicated cistron merely showed two ruddy signals. Another investigation was used to supply verification of 17p patients that did non demo the duplicate of the PMP22 cistron. The consequences showed that the FLI cistron, a cistron linked to Smith-Magenis syndrome, was duplicated in these patients. The consequences of this survey confirm that the duplicate of the PMP22 cistron is associated with CMT-IA in instances of cytogenetic duplicate of 17p. Combined cytogenetic and molecular analysis indicates the PMP22 cistron maps to band 17p12.

Chromosome 17 is non the lone chromosome venue that has been shown to play a function in CMT. Loci can differ based on the symptoms, subtypes, and manner of heritage. Autosomal dominant heritage is seen in CMT I, CMT II, and CMT X. CMT X is an X-linked signifier of CMT happening more frequently in males than females, but is considered to demo a dominant heritage form. CMT I can besides demo an autosomal recessionary form. Below is a chart bespeaking heritage form and chromosome location of each of the subtypes of CMT. ( Warner et al. 1999 )

Inheritance Pattern Chromosome venue

CMTI Autosomal dominant

Type IA 17p11.2-p12

Type IB 1q21.1-q23q

Type IC does non tag to either

CMT I Autosomal Recessive 5q23-q33, 8q24, 11q23

CMT II Autosomal dominant

Type IIA 1p35-p36

Type IIB 3q13-q22

Type IID 7p1

4

CMT X Autosomal dominant Xq13.1

CMT tends to run in households and can be passed from female parent or male parent to child. It is difficult to diagnosis instances of CMT without a household history, because symptoms are really similar to other chronic inherited or acquired neuropathies. ( Murakami et al. 1996 ) It is besides really hard to observe CMT before a kid is born. This is because the chromosomal mutant merely becomes obvious during FISH analysis. Unless there is a clinical ground given to specifically prove for CMT, physicians normally do non look for it. It is possible, nevertheless, to place unnatural genotypes of at hazard individuals for CMT.

Familial guidance of CMT households is normally limited to parents who either have the upset themselves or households who have other kids with CMT. It is the familial counsellor s duty to inform the parents of the hazards of transmittal and rede them of alternate agencies. If parents have familial proving done on their unborn kid and they discover that their kid is transporting some upset, they are given several options. These options include an abortion if adequate clip remains ( gestation presently in the first trimester ) , puting the kid in institutionalised attention one time born, or instruction and supplying support to the parents about the upset that their kid will hold.

Since CMT is non normally diagnosed before the kid is born, the familial counsellor s function is limited in these patients. They can rede the parents on the hazards of holding another kid with CMT. In the instance of CMT, familial counsellors try to deter parents from even holding kids at all if the parents are known bearers of the upset. This is because ninety-some per centum of CMT instances have been linked to a familial cause.

Unfortunately, parents do non wish to be told that they should non hold kids. Most faiths believe that kids are the merchandises of a healthy matrimony. When parents know the hazards of transmittal of CMT and have kids anyhow, they are fundamentally jeopardizing the kid s public assistance. This causes ethical issues to originate. Should parents be allowed to hold kids if they are at a higher hazard of transmittal of a familial upset? It is argued that everyone has an unalienable right to hold kids. ( Dickenson: 1995 p. 75 ) On the other manus, should this right be limited in those that are known bearers of familial diseases?

Another inquiry that is frequently raised is, if intervention options are available, such as cistron therapy or medicine, are all other concerns made nothingness? Since CMT has a strong familial nexus, it may be possible to utilize bodily cell cistron therapy when it becomes available. The ultimate accomplishment of bodily cell cistron therapy would be to replace a faulty cistron with a normal one and therefore supply a normal cistron merchandise. ( Rosenberg and Iannaccone 1995 ) Should the kid be subjected to interventions merely because their parents ignored all the warnings about the hazards? Scientists in Japan have created a solution to the job of X-linked upsets such as Duchenne s muscular dystrophy. They use a preimplantation arousing method for exclusion of male embryos ( 50 % of which have the familial disease trait ) as an option for parents at hazard ( Ijichi and Ijichi: 1996, p. 198 ) Should rear even have kids if they are utilizing such steps to avoid holding a kid with a familial disease? Since CMT can originate through X-linked traits, this intervention is a possibility for parents who are bearers and want to hold kids.

Neurogenetics has shifted focal point from clinical descriptions and categorizations to a molecular scientific discipline that has been successful in placing specific cistron changes in a important figure of major neurogenetic diseases. It is hoped that these upsets can be treated with metabolic cistron therapy to stabilise or change by reversal patterned advance. It has frequently been questioned if at-risk individuals would be interested in cognizing their hazards, and a recent estimation has indicated that the approximative size of the United States market for proving healthy people for CMT is 100,000 households. ( Rosenberg and Iannaccone 1995 ) However, there are issues refering deficient quality control over familial proving research labs. So far there has non been conclusive grounds bespeaking quality control jobs ensuing in false positives.

I feel that familial counsellors and physicians should offer options to parents who wish to hold kids. Adoption is an first-class pick. There are a figure of healthy kids in surrogate places who need a household. Alternatively of put on the lining a transmittal of a familial unwellness, parents should see giving a place to a kid who needs one. If the kid has already been conceived and parents learn that he or she has a disease, they should seek guidance and outside aid instead than give up and see an abortion. Once they know of their hazard to go through the disease onto their other kids, they should see the effects of holding more kids. Even if cistron therapy is an option, it is a really experimental and hazardous process. Hazards might outweigh the benefits, particularly if the hazards include a premature decease of the kid.

Even though causes of CMT have been determined and a cistron has been isolated, a remedy has yet to be found. Life anticipation of these patients is reasonably mean. CMT is a progressive upset ; symptoms and behaviours are expected to be more readily show themselves over clip. Research workers are presently working on cistron therapy as a possible remedy. A remedy is foreseen in the close hereafter due to progresss in genetic sciences. Technology learned from other neurogenetic diseases can be applied to CMT. This makes the undertaking of happening a remedy that much easier. I am personally in favour of advanced familial testing of myself, my household, and any kids that I might hold.

Beginnings

Dickenson, D. ( 1995 ) . Carriers of Genetic Disorder and the Right to Have Children. Acta Geneticae Medicae et Gemellologiae 44, 75-80.

Epstein, Charles J. , erectile dysfunction. The Phenotypic Mapping of Down Syndrome and Other Aneuploid Conditionss: Proceedings of a National Down Syndrome Society Conference. New York: Wiley-Liss, p. 7, 10, 187-205, 1993.

Ijichi, S. , and Ijichi, N. ( 1996 ) . Preimplantation gender finding and X-linked diseases: ethical contention. Lancet 348, 198-199.

King, P.H. , et Al. ( 1998 ) . Charcot-Marie-Tooth phenotype produced by a duplicated PMP22 cistron as a portion of a 17p trisomy-translocation to the X chromosome. Clinical Geneticss 54, 413-416.

Lovelace, Robert E. , and Howard K. Shapiro, erectile dysfunction. Charcot-Marie-Tooth Disorders:

Pathophysiology, Molecular Genetics, and Therapy. New York: Wiley-Liss, 1990.

Lupski, J. R. , et Al. ( 1992 ) . Gene dose is a mechanism for Charcot-Marie-Tooth

disease type 1A. Nature Genetics 1, 29-33.

Murakami, T. , et Al. ( 1996 ) . Charcot-Marie-Tooth Disease and Related Inherited

Neuropathies. Medicine 75, 233-250.

Roa, B. B. , et. Al. ( 1996 ) . Duplicate of the PMP22 cistron in 17p partial trisomy patients with Charcot-Marie-Tooth type-1A neuropathy. Human Genetics 97, 642-649.

Rosenberg, Roger N. , and Susan T. Iannaccone ( 1995 ) . The bar of Neurogenetic Disease. Archivess of Neurology 52, 356-362.

Valentijn, Linda J. , and Frank Bass ( 1998 ) . Familial Footing of Peripheral Neuropathies. Progress in Brain Research 117, 249-264.

Warner, Laura E. et Al. ( 1999 ) Hereditary Peripheral Neuropathies: Clinical Forms, Genetics, and Molecular Mechanisms. Annual Review of Medicine 50, 263-275.

Cite this Charcot Marie Tooth Disease Research Paper

Charcot Marie Tooth Disease Research Paper. (2017, Jul 27). Retrieved from https://graduateway.com/charcot-marie-tooth-disease-essay-research-paper/

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